Mutation data of the CTNNB1 gene

Mutation type*1 Mutation position Length of affected nucleotides Nucleotide sequence after mutation Mutation name Case # Consequence Organ Tumor Subtype/note Origin Zygosity Reference
LD 82 321   82del321 1 321-bp del at ntd 82-402 -> del at codon 28-134 Stomach gastric carcinoma Signet ring cell carcinoma HSC-39, HSC40A (cell line) Homozygous Oyama, T. et al Cancer Res 54, 6282 (1994)
M 98 1 A S33Y 1 TCT-TAT at ntd 98 -> Ser-Tyr at codon 33 Colon colorectal carcinoma ND*2 SW48 (cell line) Heterozygous Ilyas, M. et al Proc Natl Acad Sci U S A 94, 10330 (1997)
D 133 3   133delTCT 1 3-bp del of TCT at ntd 133-135 -> del of Ser at codon 45 Colon colorectal carcinoma ND HCT116 (cell line) Heterozygous Ilyas, M. et al Proc Natl Acad Sci U S A 94, 10330 (1997)
M 547 1 T A183S 1 GCT-TCT at ntd 547 -> Ala-Ser at codon 183 Colon colorectal carcinoma ND HCA46 (cell line) Heterozygous Ilyas, M. et al Proc Natl Acad Sci U S A 94, 10330 (1997)
M 734 1 C G245A 1 GGT-GCT at ntd 734 -> Gly-Ala at codon 245 Colon colorectal carcinoma ND Caco2 (cell line) Heterozygous Ilyas, M. et al Proc Natl Acad Sci U S A 94, 10330 (1997)
M 860 1 G N287S 1 AAC-AGC at ntd 860 -> Asn-Ser at codon 287 Colon colorectal carcinoma ND Colo201/205 (cell line) Homozygous Ilyas, M. et al Proc Natl Acad Sci U S A 94, 10330 (1997)
M 98 1 T S33F 1 TCT-TTT at ntd 98 -> Ser-Phe at codon 33 Uterus endometriod carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 109 1 G S37A 1 TCT-GCT at ntd 109 -> Ser-Ala at codon 37 Uterus endometriod carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 110 1 G S37C 1 TCT-TGT at ntd 110 -> Ser-Cys at codon 37 Uterus endometriod carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 121 1 G T41A 1 ACC-GCC at ntd 121-> Thr-Ala at codon 41 Uterus adenosquamous carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 121 1 G T41A 1 ACC-GCC at ntd 121-> Thr-Ala at codon 41 Uterus endometriod carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 122 1 T T41I 2 ACC-ATC at ntd 122 -> Thr-Ile at codon 41 Uterus endometriod carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 134 1 T S45F 2 TCT-TTT at ntd 134 -> Ser-Phe at codon 45 Uterus endometriod carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 134 1 G S45C 1 TCT-TGT at ntd 134 -> Ser-Cys at codon 45 Uterus endometriod carcinoma ND ND ND Fukuchi, T et al Cancer Res 58, 3526 (1998)
M 110 1 G S37C 1 TCT-TGT at ntd 110 -> Ser-Cys at codon 37 Ovary endometriod carcinoma ND ND ND Palacios, J. et al Cancer Res 58, 1344 (1998)
M 110 1 T S37F 1 TCT-TTT at ntd 110 -> Ser-Phe at codon 37 Ovary endometriod carcinoma ND ND ND Palacios, J. et al Cancer Res 58, 1344 (1998)
M 121 1 G T41A 1 ACC-GCC at ntd 121-> Thr-Ala at codon 41 Ovary endometriod carcinoma ND ND ND Palacios, J. et al Cancer Res 58, 1344 (1998)
M 94 1 T D32Y 1 GAC-TAC at ntd 94 -> Asp-Tyr at codon 32 Prostate ND ND ND ND Voeller, H. J. et al Cancer Res 58, 2520 (1998)
M 98 1 T S33F 2 TCT-TTT at ntd 98 -> Ser-Phe at codon 33 Prostate ND ND ND ND Voeller, H. J. et al Cancer Res 58, 2520 (1998)
M 121 1 G T41A 1 ACC-GCC at ntd 121-> Thr-Ala at codon 41 Prostate ND ND ND ND Voeller, H. J. et al Cancer Res 58, 2520 (1998)
D 133 3   133delTCT 1 3-bp del of TCT at ntd 133-135 -> del of Ser at codon 45 Prostate ND ND ND ND Voeller, H. J. et al Cancer Res 58, 2520 (1998)
LD 13+58 677   IVS2+58del677 1 deletion of exon 3 Colon primary colorectal carcinoma w/o APC mutation ND Homozygous Iwao, K. et al Cancer Res 58, 1021 (1998)
LD 13+61 760   IVS2+61del760 1 deletion of exon 3 Colon primary colorectal carcinoma w/o APC mutation ND Heterozygous Iwao, K. et al Cancer Res 58, 1021 (1998)
LD 13+63 656   IVS2+63del656 1 deletion of exon 3 Colon primary colorectal carcinoma w/o APC mutation ND Heterozygous Iwao, K. et al Cancer Res 58, 1021 (1998)
LD 13+166 653   IVS2+166del653 1 deletion of exon 3 Colon primary colorectal carcinoma w/o APC mutation ND Heterozygous Iwao, K. et al Cancer Res 58, 1021 (1998)
LD 13+282 407   IVS2+282del407 1 deletion of exon 3 Colon primary colorectal carcinoma w/o APC mutation ND Heterozygous Iwao, K. et al Cancer Res 58, 1021 (1998)
LD 13+379 333   IVS2+379del333 1 deletion of exon 3 Colon primary colorectal carcinoma w/o APC mutation ND Heterozygous Iwao, K. et al Cancer Res 58, 1021 (1998)
LD 68 234   68del234 1 234-bp del at ntd 68 - IVS3-128 -> del at codon 23-80 Colon primary colorectal carcinoma w/o APC mutation ND Heterozygous Iwao, K. et al Cancer Res 58, 1021 (1998)
LD 14-45 195   IVS2-45del195 1 195-bp del at IVS2-45 - ntd 162 -> del at codon 5-54 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 94 1 A D32N 3 GAC-AAC at ntd 94 -> Asp-Asn at codon 32 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 94 1 T D32Y 2 GAC-TAC at ntd 94 -> Asp-Tyr at codon 32 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 97 1 C S33P 1 TCT-CCT at ntd 97 -> Ser-Pro at codon 33 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 101 1 T G34V 1 GGA-GTA at ntd 101-> Gly-Val at codon 34 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
ID 107 52 T 107indel52->T 1 52-bp del at ntd 107-158 and ins T -> del at codon 36-53 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 121 1 G T41A 1 ACC-GCC at ntd 121-> Thr-Ala at codon 41 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 133 1 C S45P 2 TCT-CCT at ntd 133 -> Ser-Pro at codon 45 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 134 1 T S45F 2 TCT-TTT at ntd 134 -> Ser-Phe at codon 45 Liver primary hepatocellular carcinoma ND ND ND Miyoshi, Y. et al Cancer Res 58, 2524 (1998)
M 110 1 G S37C 1 TCT-TGT at ntd 110 -> Ser-Cys at codon 37 ND Sporadic medulloblastoma Turcot's syndrome ND ND Zurawel, R. et al Cancer Res 58, 896 (1998)
M 110 1 G S37C 2 TCT-TGT at ntd 110 -> Ser-Cys at codon 37 ND Sporadic medulloblastoma Turcot's syndrome ND ND Zurawel, R. et al Cancer Res 58, 896 (1998)
M 94 1 A D32N 1 GAT-AAT at ntd 94 -> Asp-Asn at codon 32 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 95 1 G D32G 1 GAT-GGT at ntd 95 -> Asp-Gly at codon 32 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 94 1 A D32N 1 GAT-AAT at ntd 94 -> Asp-Asn at codon 32 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 98 1 T S33F 1 TCT-TTT at ntd 98 -> Ser-Phe at codon 33 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 101 1 A G34E 1 GGA-GAA at ntd 101-> Gly-Glu at codon 34 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 101 1 A G34E 1 GGA-GAA at ntd 101-> Gly-Glu at codon 34 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 101 1 A G34E 1 GGA-GAA at ntd 101-> Gly-Glu at codon 34 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 122 1 T T41I 1 ACC-ATC at ntd 122 -> Thr-Ile at codon 41 Colon (Rat) Azoxymethane-induced colon tumor ND ND ND Takahashi, M. et al Cancer Res 58, 42 (1998)
M 94 1 A D32N 3 GAT-AAT at ntd 94 -> Asp-Asn at codon 32 Colon (Rat) Heterocyclic amines-induced colon tumor ND ND ND Dashwood, R. H. et al Cancer Res 58, 1127 (1998)
M 101 1 T G34V   GGA-GTA at ntd 101-> Gly-Val at codon 34 Colon (Rat) Heterocyclic amines-induced colon tumor ND ND ND Dashwood, R. H. et al Cancer Res 58, 1127 (1998)
M 101 1 A G34E   GGA-GAA at ntd 101-> Gly-Glu at codon 34 Colon (Rat) Heterocyclic amines-induced colon tumor ND ND ND Dashwood, R. H. et al Cancer Res 58, 1127 (1998)
M 104 1 G I35S 1 ATC-AGC at ntd 104 -> Ile-Ser at codon 35 Colon (Rat) Heterocyclic amines-induced colon tumor ND ND ND Dashwood, R. H. et al Cancer Res 58, 1127 (1998)
M 110 1 G S37C 2 TCT-TGT at ntd 110 -> Ser-Cys at codon 37 Colon (Rat) Heterocyclic amines-induced colon tumor ND ND ND Dashwood, R. H. et al Cancer Res 58, 1127 (1998)

*1 Abbreviations are as follows: M, Missense; D, Deletion; ID, Insertion and Deletion; LD, Large Deletion.
*2 Abbreviation is as follows: ND, Not Described.







Last updated 17 July 1999